Journal of Vascular and Interventional Radiology
Volume 19, Issue 1 , Pages 47-57 , January 2008

Acrylamido Polyvinyl Alcohol Microspheres for Uterine Artery Embolization: 12-month Clinical and MR Imaging Results

  • Thomas J. Kroencke, MD

      Affiliations

    • Department of Radiology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • T.J.K. has served as an advisor to Biocompatibles and is currently an advisor to Terumo, and has received honoraria for presentations relating to the use of BeadBlock. None of the other authors have identified a conflict of interest.
    • Corresponding Author InformationAddress correspondence to T.J.K.
  • ,
  • Christian Scheurig, MD

      Affiliations

    • Department of Radiology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
  • ,
  • Leo E.H. Lampmann, MD, PhD

      Affiliations

    • Department of Radiology, St. Elisabeth Ziekenhuis, Tilburg, The Netherlands.
  • ,
  • Peter F. Boekkooi, MD, PhD

      Affiliations

    • Department of Radiology, St. Elisabeth Ziekenhuis, Tilburg, The Netherlands.
  • ,
  • Lutz Kissner, MD

      Affiliations

    • Department of Gynecology and Obstetrics, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
  • ,
  • Claudia Kluner, MD

      Affiliations

    • Department of Radiology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
  • ,
  • Wilko Weichert, MD

      Affiliations

    • Department of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
  • ,
  • Bernd Hamm, MD

      Affiliations

    • Department of Radiology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
  • ,
  • Paul N.M. Lohle, MD, PhD

      Affiliations

    • Department of Radiology, St. Elisabeth Ziekenhuis, Tilburg, The Netherlands.

Received 26 February 2007 ,Revised 13 August 2007 ,Accepted 14 August 2007.

References 

  1. Spies JB, Bruno J, Czeyda-Pommersheim F, Magee ST, Ascher SA, Jha RC. Long-term outcome of uterine artery embolization of leiomyomata. Obstet Gynecol. 2005;106:933–939
  2. Lohle PN, Boekkooi FP, Smeets AJ, et al. Limited uterine artery embolization for leiomyomas with tris-acryl gelatin microspheres: 1-year follow-up. J Vasc Interv Radiol. 2006;17:283–287
  3. Katsumori T, Kasahara T, Akazawa K. Long-term outcomes of uterine artery embolization using gelatin sponge particles alone for symptomatic fibroids. AJR Am J Roentgenol. 2006;186:848–854
  4. Goodwin SC, Vedantham S, McLucas B, Forno AE, Perrella R. Preliminary experience with uterine artery embolization for uterine fibroids. J Vasc Interv Radiol. 1997;8:517–526
  5. Goodwin SC, Bradley LD, Lipman JC, et al. Uterine artery embolization versus myomectomy: a multicenter comparative study. Fertil Steril. 2006;85:14–21
  6. Pron G, Bennett J, Common A, Wall J, Asch M, Sniderman K. The Ontario Uterine Fibroid Embolization Trial (Part 2: uterine fibroid reduction and symptom relief after uterine artery embolization for fibroids). Fertil Steril. 2003;79:120–127
  7. Pelage JP, Laurent A, Wassef M, et al. Uterine artery embolization in sheep: comparison of acute effects with polyvinyl alcohol particles and calibrated microspheres. Radiology. 2002;224:436–445
  8. Spies JB, Coyne K, Guaou Guaou N, Boyle D, Skyrnarz-Murphy K, Gonzalves SM. The UFS-QOL, a new disease-specific symptom and health-related quality of life questionnaire for leiomyomata. Obstet Gynecol. 2002;99:290–300
  9. Pelage JP, Le Dref O, Beregi JP, et al. Limited uterine artery embolization with tris-acryl gelatin microspheres for uterine fibroids. J Vasc Interv Radiol. 2003;14:15–20
  10. Goodwin SC, Bonilla SM, Sacks D, et al. Reporting standards for uterine artery embolization for the treatment of uterine leiomyomata. J Vasc Interv Radiol. 2001;12:1011–1020
  11. Orsini LF, Salardi S, Pilu G, Bovicelli L, Cacciari E. Pelvic organs in premenarcheal girls: real-time ultrasonography. Radiology. 1984;153:113–116
  12. Kawakami S, Togashi K, Konishi I, et al. Red degeneration of uterine leiomyoma: MR appearance. J Comput Assist Tomogr. 1994;18:925–928
  13. Leoni CJ, Potter JE, Rosen MP, Brophy DP, Lang EV. Classifying complications of interventional procedures: a survey of practicing radiologists. J Vasc Interv Radiol. 2001;12:55–59
  14. Lepine LA, Hillis SD, Marchbanks PA, et al. Hysterectomy surveillance—United States, 1980-1993. MMWR CDC Surveill Summ. 1997;46:1–15
  15. Myers ER, Barber MD, Gustilo-Ashby T, Couchman G, Matchar DB, McCrory DC. Management of uterine leiomyomata: what do we really know?. Obstet Gynecol. 2002;100:8–17
  16. Vessey MP, Villard-Mackintosh L, McPherson K, Coulter A, Yeates D. The epidemiology of hysterectomy: findings in a large cohort study. Br J Obstet Gynaecol. 1992;99:402–407
  17. Edozien LC. Hysterectomy for benign conditions. Br Med J. 2005;330:1457–1458
  18. Nevadunsky NS, Bachmann GA, Nosher J, Yu T. Women’s decision-making determinants in choosing uterine artery embolization for symptomatic fibroids. J Reprod Med. 2001;46:870–874
  19. Worthington-Kirsch R, Spies JB, Myers ER, et al. The Fibroid Registry for Outcomes Data (FIBROID) for uterine embolization: short-term outcomes. Obstet Gynecol. 2005;106:52–59
  20. Spies JB, Myers ER, Worthington-Kirsch R, Mulgund J, Goodwin S, Mauro M. The FIBROID registry: symptom and quality-of-life status 1 year after therapy. Obstet Gynecol. 2005;106:1309–1318
  21. Walker WJ, Barton-Smith P. Long-term follow up of uterine artery embolisation—an effective alternative in the treatment of fibroids. Br J Obstet Gynaecol. 2006;113:464–468
  22. Scheurig C, Gauruder-Burmester A, Kluner C, et al. Uterine artery embolization for symptomatic fibroids: short-term versus mid-term changes in disease-specific symptoms, quality of life and magnetic resonance imaging results. Hum Reprod. 2006;21:3270–3277
  23. Pelage JP, Guaou NG, Jha RC, Ascher SM, Spies JB. Uterine fibroid tumors: long-term MR imaging outcome after embolization. Radiology. 2004;230:803–809
  24. Chrisman HB, West D, Corpuz B, et al. Primary failure of uterine artery embolization: use of magnetic resonance imaging to select patients for repeated embolization. J Vasc Interv Radiol. 2005;16:1143–1147
  25. Kroencke TJ, Scheurig C, Schink T, Zimmermann E, Hamm B. Devascularization of fibroids after UAE determines clinical outcome—a prospective study. 2006;Presented at the 2006 Annual Meeting of the Society of Interventional Radiology; March 30 through April 4,; Toronto, ON, Canada.
  26. Yousefi S, Czeyda-Pommersheim F, White AM, Banovac F, Hahn WY, Spies JB. Repeat uterine artery embolization: indications and technical findings. J Vasc Interv Radiol. 2006;17:1923–1929
  27. Spies JB, Benenati JF, Worthington-Kirsch RL, Pelage JP. Initial experience with use of tris-acryl gelatin microspheres for uterine artery embolization for leiomyomata. J Vasc Interv Radiol. 2001;12:1059–1063
  28. Banovac F, Ascher SM, Jones DA, Black MD, Smith JC, Spies JB. Magnetic resonance imaging outcome after uterine artery embolization for leiomyomata with use of tris-acryl gelatin microspheres. J Vasc Interv Radiol. 2002;13:681–688
  29. Namur J, Wassef M, Pelage JP, Laurent A. Arterial location of three sizes of Embospheres and BeadBlock in sheep uterus models. 2005;Presented at the Annual Scientific Meeting of the Cardiovascular and Interventional Radiology Society of Europe; September 10–14,; Nice, France.
  30. Dhand S, Rajeswaran S, Chrisman HB, et al. Evaluation of the embolic agent Head Block in the tretament of uterine fibroids with uterine artery embolization. J Vasc Interv Radiol. 2007;18(suppl):S13

 From the SIR 2007 Annual Meeting.

 The study was supported by a grant of Biocompatibles, Farnham, Surrey, UK.

PII: S1051-0443(07)01129-3

doi: 10.1016/j.jvir.2007.08.019

Journal of Vascular and Interventional Radiology
Volume 19, Issue 1 , Pages 47-57 , January 2008