Journal of Vascular and Interventional Radiology
Volume 20, Issue 7 , Pages 896-902 , July 2009

Arterial Chemoembolization/Embolization and Early Complications after Hepatocellular Carcinoma Treatment: A Safe Standardized Protocol in Selected Patients with Child Class A and B Cirrhosis

  • Giada Pietrosi, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • Corresponding Author InformationAddress correspondence to G.P.
    • ,
  • Roberto Miraglia, MD

      Affiliations

    • Department of Interventional Radiology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Angelo Luca, MD

      Affiliations

    • Department of Interventional Radiology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Giovanni Battista Vizzini, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Daniela Fili', MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Volpes Riccardo, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Adele D'Antoni, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Ioannis Petridis, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Luigi Maruzzelli, MD

      Affiliations

    • Department of Interventional Radiology, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Domenico Biondo, MsC

      Affiliations

    • Office of Research, Health and Biomedical Sciences, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy
    • ,
  • Bruno Gridelli, MD

      Affiliations

    • Medical and Scientific Director, Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Via Tricomi 1, 90127 Palermo, Italy

Received 29 February 2008 ,Revised 20 February 2009 ,Accepted 16 March 2009.

References 

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics 2002. CA Cancer J Clin. 2005;55:74–108
  2. Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology. 2003;37:429–442
  3. Marelli L, Stigliano R, Triantos C, et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? (A systematic review of cohort and randomized studies). Cardiovasc Intervent Radiol. 2007;30:6–25
  4. Groupe d'Etude et de traitement du Carcinome hepatocellulaire. A comparison of Lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med. 1995;332:1256–1261
  5. Ngan H, Lai CL, Fan ST, Lai EC, Yuen WK, Tso WK. Transcatheter arterial chemoembolization in inoperable hepatocellular carcinoma: four-year follow up. J Vasc Interv Radiol. 1996;7:419–425
  6. Pelletier G, Roche A, Ink O, et al. A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. J Hepatol. 1990;11:181–184
  7. Llado' L, Virgili J, Figueras J, et al. A prognostic index of the survival of patients with unresectable hepatocellular carcinoma after transcatheter arterial chemoembolization. Cancer. 2000;88:50–57
  8. Poon RT, Ngan H, Lo CM, Liu CL, Wong J. Transarterial chemoembolization for inoperable hepatocellular carcinoma and postresection intrahepatic recurrence. J Surg Oncol. 2000;73:109–114
  9. Llovet JM, Real MI, Montana X, et al. Arterial embolization or chemoembolization versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet. 2002;359:1734–1739
  10. Chan AO, Yuen MF, Hui CK, Tso WK, Lai CL. A prospective study regarding the complications of transcatheter intraarterial Lipiodol chemoembolization in patients with hepatocellular carcinoma. Cancer. 2002;94:1747–1752
  11. Chen MS, Li JQ, Zhang YQ, et al. High-dose iodized oil transcatheter arterial chemoembolization for patients with large hepatocellular carcinoma. World J Gastroenterol. 2002;8:74–78
  12. Hsieh CB, Chang HM, Chen TW, et al. Comparison of transcatheter arterial chemoembolization, laparoscopic radiofrequency ablation, and conservative treatment for decompensated cirrhotic patients with hepatocellular carcinoma. World J Gastroenterol. 2004;10:505–508
  13. Liem MS, Poon RT, Lo CM, Tso WK, Fan ST. Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation. World J Gastroenterol. 2005;11:4465–4471
  14. Kiely JM, Rilling WS, Touzios JG, et al. Chemoembolization in patients at high risk: results and complications. J Vasc Interv Radiol. 2006;17:47–53
  15. Brown DB, Gould JE, Gervais DA, et al. Transcatheter therapy for hepatic malignancy: standardization of terminology and reporting criteria. J Vasc Interv Radiol. 2007;18:1469–1478
  16. Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649–655
  17. Bruix J, Sherman M, Llovet JM, et al. Clinical management of hepatocellular carcinoma: conclusions of the Barcelona-2000 EASL Conference. J Hepatol. 2001;35:421–430
  18. Llovet JM, Bustamante J, Castells A, et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of the therapeutic trials. Hepatology. 1999;29:62–67
  19. Northup PG, Wanamaker RC, Lee VD, Adams RB, Berg CL. Model for end-stage liver disease (MELD) predicts nontransplant surgical mortality in patients with cirrhosis. Ann Surg. 2005;242:244–251
  20. Vizzini GB, Luca A, Marino I. Hepatitis B virus reactivation after a single session of transarterial chemoembolization in patients with hepatocellular carcinoma (Research letter). Ann Intern Med. 2003;138:691–692
  21. Miraglia R, Pietrosi G, Maruzzelli L, et al. Efficacy of transcatheter embolization/chemoembolization (TAE/TACE) for the treatment of single hepatocellular carcinoma. World J Gastroenterol. 2007;13:2952–2955
  22. Savastano S, Miotto D, Casarrubea G, Teso S, Chiesura-Corona M, Feltrin GP. Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with Child's grade A or B cirrhosis: a multivariate analysis of prognostic factors. J Clin Gastroenterol. 1999;28:334–340
  23. Varela M, Real MI, Burrel M, et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and epirubicin pharmacokinetics. J Hepatol. 2007;46:474–481
  24. Malagari K, Chatzimichael K, Alexopoulou E, et al. Transarterial chemoembolization of unresectable hepatocellular carcinoma (HCC) with drug eluting beads (DEB): results of an open label study of 62 patients. Cardiovasc Intervent Radiol. 2008;31:269–280

 None of the authors have identified a conflict of interest.

PII: S1051-0443(09)00331-5

doi: 10.1016/j.jvir.2009.03.032

Journal of Vascular and Interventional Radiology
Volume 20, Issue 7 , Pages 896-902 , July 2009

Article Tools