Journal of Vascular and Interventional Radiology
Volume 21, Issue 1 , Pages 101-107 , January 2010

Radiofrequency Endothelial Ablation Prevents Recanalization after Endovascular Coil Occlusion: In Vitro and in Vivo Assessment

  • Jean Raymond, MD

      Affiliations

    • Interventional Neuroradiology Research Laboratory, Research Center, Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, 1560 Sherbrooke East Pavillon Simard, Ste Z12909, Montreal, Quebec, Canada
    • Corresponding Author InformationAddress correspondence to J.R.
    • ,
  • Pierre Savard, PhD

      Affiliations

    • Institute of Biomedical Engineering, École Polytechnique de Montréal, Canada
    • ,
  • Igor Salazkin, MD

      Affiliations

    • Interventional Neuroradiology Research Laboratory, Research Center, Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, 1560 Sherbrooke East Pavillon Simard, Ste Z12909, Montreal, Quebec, Canada
    • ,
  • Fatiha Bouzeghrane, PhD

      Affiliations

    • Interventional Neuroradiology Research Laboratory, Research Center, Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, 1560 Sherbrooke East Pavillon Simard, Ste Z12909, Montreal, Quebec, Canada

Received 8 May 2008 ,Revised 14 September 2009 ,Accepted 16 September 2009.

References 

  1. Molyneux A, Kerr R, Stratton I, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet. 2002;360:1267–1274
  2. Raymond J, Guilbert F, Georganos S, et al. Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke. 2003;34:421–427
  3. The CARAT Investigators. Rates of delayed rebleeding from intracranial aneurysms are low after surgical and endovascular treatment. Stroke. 2006;37:1437–1442
  4. Raymond J, Leblanc P, Morel F, Salazkin I, Gevry G, Roorda S. Beta radiation and inhibition of recanalization after coil embolization of canine arteries and experimental aneurysms: how should radiation be delivered?. Stroke. 2003;34:1262–1268
  5. Raymond J, Darsaut T, Salazkin I, Gevry G, Bouzeghrane F. Mechanisms of occlusion and recanalization in canine carotid bifurcation aneurysms embolized with platinum coils: an alternative concept. AJNR Am J Neuroradiol. 2008;29:745–752
  6. Raymond J, Guilbert F, Metcalfe A, Gevry G, Salazkin I, Robledo O. Role of the endothelial lining in recurrences after coil embolization: prevention of recanalization by endothelial denudation. Stroke. 2004;35:1471–1475
  7. Raymond J. Methods and devices for endothelial denudation to prevent recanalization after embolization. US patent 60/502,255 September 2003;
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  9. Raymond J, Salazkin I, Georganos S, et al. Endovascular treatment of experimental wide neck aneurysms: comparison of results using coils or cyanoacrylate with the assistance of an aneurysm neck bridge device. AJNR Am J Neuroradiol. 2002;23:1710–1716
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  16. Nomori H, Imazu Y, Watanabe K, et al. RFA of pulmonary tumors and normal lung tissue in swine and rabbits. Chest. 2005;127:973–977
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  21. Shimko N, Savard P, Shah K. Radio frequency perforation of cardiac tissue: modelling and experimental results. Med Biol Eng Comput. 2000;38:575–582

 This work was supported by grants from the Canadian Institute of Health research (MOP-44062) and Fondation des Maladies du Cœur du Québec to J.R.

 None of the authors have identified a conflict of interest.

PII: S1051-0443(09)00957-9

doi: 10.1016/j.jvir.2009.09.015

Journal of Vascular and Interventional Radiology
Volume 21, Issue 1 , Pages 101-107 , January 2010

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