Journal of Vascular and Interventional Radiology
Volume 21, Issue 4 , Pages 443-451, April 2010

Intraarterial Autologous Implantation of Adult Stem Cells for Patients with Parkinson Disease

  • Augusto Brazzini, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Medical School of the University of San Martin de Porres, Lima, Perú
    • Corresponding Author InformationAddress correspondence to A.B., Instituto Brazzini Radiólogos, Jorge Basadre 223 San Isidro, Lima 27, Perú
    • ,
  • Raúl Cantella, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Medical School of the University of San Martin de Porres, Lima, Perú
    • ,
  • Antonio De la Cruz, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Hospital Nacional Daniel A. Carrión, Lima, Perú
    • ,
  • Jorge Yupanqui, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Laboratorios Cantella, Lima, Perú
    • ,
  • Carlos León, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Medical School of the University of San Martin de Porres, Lima, Perú
    • Instituto Peruano de Paternidad Responsable, Lima, Perú
    • ,
  • Tamara Jorquiera, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Medical School of the University of San Martin de Porres, Lima, Perú
    • ,
  • Mariana Brazzini, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Hospital Guillermo Almenara Irigoyen, Lima, Perú
    • ,
  • Melitón Ortega, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú
    • Hospital Nacional José Casimiro Ulloa, Lima, Perú
    • ,
  • Luis N. Saenz, MD

      Affiliations

    • Brazzini Institute of Radiology, Lima, Perú

Received 26 November 2007; received in revised form 18 November 2009; accepted 19 January 2010.

Purpose

To evaluate the feasibility, safety, and effectiveness of intraarterial autologous implantation of adult stem cells for Parkinson disease (PD).

Materials and Methods

From June 2006 to August 2008, 36 men and 14 women (mean age, 62.5 years ± 10.4; range, 38–81 y) with PD (mean duration, 9.3 years; range, 1–28 y) underwent autologous implantation of stem cells with superselective arterial catheterization. Patients were evaluated with clinical and neurologic examinations; internationally recognized scales for the evaluation of PD, disability, activities of daily living, depression, and quality of life (QOL); as well as videos, magnetic resonance (MR) imaging, and MR spectroscopy. Stem cells were implanted in the posterior region of the circle of Willis. Patients were evaluated according to clinical measures. Comparison was made versus data collected from all scales before treatment, as well as videos and spectroscopy in eight patients.

Results

In a mean follow-up of 7.4 months ± 4.5 (range, 1–18 months), patients showed a median improvement of 51.1% and quartile deviation (QD) of 24.8% on the Unified PD Rating Scale. They showed significant improvement in disability, activities of daily living, depression, and QOL (P < .5). No complications were observed. In eight patients, follow-up MR spectroscopy revealed mean improvements in n-acetylaspartate/creatine ratio from 1.805 to 2.07 (12.8%) and from 1.25 to 1.88 (43.56%) in right and left basal ganglia, respectively, versus preprocedural values (P < .05).

Conclusions

Treatment of PD with intraarterial autologous implantation of adult stem cells is feasible and safe and results in improved severity of disease and QOL.

Abbreviations: ADC, apparent diffusion coefficient, NAA, n-acetylaspartate, NUDS, Northwestern University Disability Scale, PD, Parkinson disease, QD, quartile deviation, UPDRS, Unified Parkinson Disease Rating Scale

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 From the SIR 2008 Annual Meeting.

 None of the authors have identified a conflict of interest.

PII: S1051-0443(10)00087-4

doi:10.1016/j.jvir.2010.01.008

Refers to erratum:

  • Intraarterial Autologous Implantation of Adult Stem Cells for Patients with Parkinson Disease

    Journal of Vascular and Interventional Radiology July 2010 (Vol. 21, Issue 7, Page 1141)

Journal of Vascular and Interventional Radiology
Volume 21, Issue 4 , Pages 443-451, April 2010

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